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Amikacin Injection

Category: Antibiotics and Anti- Infectives
Each vial contains:-
Amikacin - 100mg, 250mg and 500mg
Quality Specification:
Chromatographic Purity - NLT 99.5%
Pack Size : vialM

Composition : 100mg/2ml, 250 mg/2ml & 500mg/2ml
Amikacin:It is semisynthetic aminoglycoside virtually identical to its parent compound kanamycin. Amikacin is effective against a variety of aerobic gram-negative bacilli including those that are resistant to gentamicin and other Aminoglycosides (Escherichia Coli, Pseudomonas Aeruginosa, Indole positive and negative Proteus species Klebsiella, Enterobacter, Serratia, Acinetobacter, Citobacter Freundii and providencia stuarti). It is effective against both penicillinase and non-penicillinase producing Staphylococcus Aureus. Amikacin shows excellent activity against Mycobacterium Tuberculosis and Atypical Mycobacteria.
Indications :Bacteraemias, septicaemias, respiratory tract, bone and joints, CNS (including meningitis), soft tissue, intra-abdominal infections (including peritonitis), burns and post-operative infections.
Dosage : IM route for Adults, Children: 15 mg/kg body weight/day in 2 or 3 divided doses. Max of 1.5 gm/day. Neonatals: 10 mg/kg body weight followed by 7.5 mg/kg every 12 hours IV route dosage is identical, injection spread over 2-3 mins or a slow IV infusion spread over a period of 30-60 mins and for infants and neonatals 1-2 hours.
Contra-Indications:Known hypersensitive to aminoglycoside.
Special Precautions:Impaired renal function, ensure adequate hydration.
Paediatrics :Use with caution.
Pregnancy: Contra-indicated
Lactation: Contra-indicated
Elderly :Use with caution.
Side-Effects: Contra-indicated
Elderly :Ototoxicity, Nephrotoxicity, Neuromuscular Blockade, Skin rash, Tremors, Eosinophlia, Nausea, Vomiting.
Purity :Not less than 99%.
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