| Category: Anticancer
Each vial contains:-
Cisplatin- 10mg and 50mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
It is a platinum coordination complex. It causes cross linking of DNA; favoured site being N7 of guanine residue. It can also react with –SH groups in proteins and has radiomimetic property. It is bound to plasma proteins, enters, tissues & is slowly excreted unchanged in urine. Cisplatin is very effective in metastatic testicular & ovarian carcinoma. It has found use in some other solid tumours as well.
| Composition : | 10mg/20ml, 50mg/100ml | | Indication : | Metastatic testicular and overian carcinoma, advanced bladder, Head & neck cancer. | | Dosage :- | Admin by slow infusion 10-60 mg or as required. | | Contra Indications :- | Pregnancy, lactation hypersensitivity, renal impairment. | | Special Precautions :- | Maintain good hydration. Shock like state sometimes occurs during i.v. infusion,. Monitor haematological, neurological status & renal functions. Hypomagnesaemia. Hypocalcaemia. Hyperuricaemia. | | Paediatrics : | Not usually prescribed. The risk of hearing loss is increased. | | Pregnancy :- | Not usually prescribed. | | Lactation :- | Not advised. | | Elderly :- | Reduced dose may be necessary. | | Side Effects :- | Nausea, vomiting, Tinnitus, deafness, neuropathy, nephrotoxicity, electrolyte imbalance. | | Drug Interactions :- | Potentiates neurotoxicity with aminoglycosides. Ideal combination with other cytotoxic drugs.Synergistic with 5-fluorouracil and etoposide. | | Purity : | Not less than 99%. |
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