|Composition : ||5gm/50ml|
|Indications : ||Orally used for prevention of graft rejection after kidney, liver, heart, lung, pancreas. By IV infusion used in bone marrow transplant. |
|Contraindications : ||Hypersensitivity. |
Warnings - Cyclosporine when used in higher doses can cause hepatotoxicity and nephrotoxicity. Vaccinationus are less effective with its use.
|Safety Profile : ||Elderly, thyrotoxicosis, renal or hepatic diseases and acute myocardial infection. |
|Adverse Effects : ||Hypertension, renal dysfunction hirsutism, acne, tremor, convulsions Gum hyperplasia, Diarrhoea, parasthesias, Flushing, leucopenia, hepatotoxicity and abdominal discomfort. |
|Drug Interactions : ||Nephrotoxicity is potentiated by Vancomycin, Trimethoprim with Sulfamethoxazole, Aminoglycosides, Melphalan, Amphotericin B, Azapropazon, Diclofenac, Ketoconazole, Cimetidine, Ranitidine and Tracolimus. |
Blood levels of cyclosporine are increased by Nicardipine, Verapamil, Ketoconazole, Fluconazole, Itraconazole, Danazole, Bromocriptine, Metoclopramide, Erythromycin and Methylprednisolone. Blood levels of cyclosporine are decreased by Rifampicin, Phenytoim, Phenobarbitol and Carbemazepine.
|Dosage : ||Orally (First dose is given in the amount of 10-15 mg/kg/ 4-12 hours before transplantation. This dose is continued daily for 1-2 weeks after which a maintenance dose of 2-6 mg/kg/day is continued)|
I.V.inf : Starting dose one day before the transplantation. 3-5 mg/kg/day. Continue for 2 weeks after transplant. Then oral maintenance dose of 12.5mg./kg/day in two divided doses for six month to a year.
|Purity :||Not less than 99%.|