| It is an antibiotic produced by various
species of streptomyces. It exerts an inhibitory action on Gram +ve and -ve
bacteria and some fungi. Because of its cytotoxic action it is used in
palliative treatment of ceratin type of cancer.
| Composition : | 500mgmcg |
| Indications : | Wilm's tumour, C tests, ca uterus, choriocarcinoma, rhabdomyo-sarcoma, Ewing's sarcoma. | | Contraindications : | Active infection with chicken pox or herpes zoster ( a severe generalized form of disease may occur), pregnancy, infants< 12 months. | | Safety Profile : | It is a highly toxic drug. Inhalation of dust or vapours and contact with skin or mucous membrane especially eyes should be avoided. | | Adverse Effects : | Nausea, vomiting, malaise, fatigue, cheilitis, dysphagia, bone marrow depression gastric ulceration, hepatitis, hepatomegaly, abnormal liver, functions, alopecia, skin eruptions. | | Dosage : | Adult : 15 ug/kg or 400-600 ug / m² daily i.v for 5 days. Children: 15 ug/kg i.v for 5 days or 2500 ug/m² i.v over 1 week. | | Purity : | Not less than 99%. | |
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