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Dalteparin Injection

Its is a low molecular weight heparin (LMWH). It potentiates the inhibition of factor x and thrombin by antithrombin. It has relatively less effect on platelet adhesiveness.
Composition : 2500IU /0.2 ml, 5000IU/0.2ml,10000IU/mg
Indications : Unstable angina and non Q-wave myocardial infarction. Deep vein thrombosis and as preventive agent for clotting in extracorporeal system in heamodialysis.
Contraindications : Cerebral hemorrhage, ulcer in GIT., coagulation disorders, septic endocarditis, and surgical procedures of CNS, eye and ears.
Safety Profile : Thrombocytopenia, platelet dysfunction, uncontrolled hypertension, diabetic retinopathy, and pregnancy
Adverse Effects : Bleeding, sub-cutaneous haematoma and thrombocytopenia.
Drug Interactions : NSAIDs, Vitamin K antagonists may increase its activity. However, low dose aspirin may be continued unless some other contraindication is present.
Dosage :120 IU/kg body weight by sub-cutaneous route. Maximum dose 10,000 IU/12 hrs. Treatment should be continued for at least 6 days, or longer.
Purity :Not less than 99%.
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