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Dexamethasone Injection

Category: Anti inflammatory & Antiallergics
Each vial contains:
Dexamethasone….. 0.1%
Quality Specification:
Chromatographic Purity: NLT 99.5%
Pack Size : 5ml , 10ml eye drops & 30 ml injection

Composition : 8mg/2ml, 40mg/10ml, 120mg/30ml
Dexamethasone: Very potent and highly selective glucocorticoid , long acting. Causes marked, pituitary-adrenal suppression , but fluid retention and hypertension are not a problem. It meets any emergency with intensified potency and strikingly repid corticosteroid action, thus ensuring speedy reversal of the situation in the patients favour.
Indications:Allergic reactions, pre & post-operatively. Acute stage of infections, poisoning, adrenocortical insufficiency, shock, acute dermatological disorders, rheumatic disorders, ophthalmologic disorders.
Dosage: 4-20 mg/kg i.v. infusion or i.m. infusion or i.m. 0.5-5mg/day orally.
Contra-Indications:Renal failure, diabetes mellitus, psychosis, osteoporosis. Pregnancy. CHF, tuberculosis & other systemic infections.
Special Precautions: May reduce the response of the pituitary-adrenal axis to stress. Glaucoma, epilepsy, hypertension. Liver dysfunction. Elderly.
Side-Effects: Cushing ‘s habitus (rounded face, narrow mouth). Fragile skin, easy bruising, telengiectasis, hirsutism. Cutaneous atrophy occurs with topical use. Hyperglycaemia, glycosuria, muscular weaknees. Delayed healing of wounds & surgical incisions.
Drug Interactions: Phenytoin, phenobarb, ephedrine and rifampicin reduce efficacy G.I.absorption reduced by magnesium trisilicate. Salicylates efficacy reduced.
Purity :Not less than 99%.
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