| Category: Anticancer
Each vial contains:-
Docetaxel….. 20mg, 80 mg and 120mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
It is an anti-neoplastic agent.
| Composition : | 20mg/0.5 ml, 80mg/2ml, & 120mg/3ml | | Indication : | Cancer : Breast, non-small cell lung cancer, prostate, bladder, stomach, Esophagus, overy,head and neck. | | Dosage :- | Administered parenterally. The dose should be individualized depending on the size of the patient and whether or not other medicines are also being taken. Adults: 60 to 100 mg /1.73 ml intravenously. | | Contra Indications :- | Hypersensitivity , alcohol abuse or history of, chickenpox, herps zoster, fluid in lungs, infection , liver disease. | | Special Precautions :- | Immunization specifically persons living in the patient’s household should not take oral polio vaccine. | | Paediatrics : | Only limited studies are done. | | Pregnancy :- | Contraindicated. | | Lactation :- | Generally not recommended. | | Elderly :- | Use with caution. | | Side Effects :- | Mild nausea and vomiting, headache, palpitation, tightness in chest, chest pain , heart problem , hypotension, or hypertension , congestion ,diarrhoea, arthalgia, myalgia, puffiness of face, stomatitis , oedema, weight gain , tingling and numbness of face ,stomatitis, extremities , black- tarry stools , hematuria, difficult and painful alopecia , induration at the site of injection . | | Drug Interactions :- | Amphotericin- B , ketoconazole , antithyroid agents ,erythromycin troleandomycin , colchicine, flucytosine, ganciclovir , zidovudine, interferon, cyclophosphamide, orphenadine, testosterone, midazolam, radiation, therapy. |
| Indication : | Malignant lymphoma. Gastro-intestinal tract carcinoma. Bronchogenic, bladder, breast & overian carcinoma. Wilm’s tumour. Acute my eloblastic leukaemia. Soft tissue & bone sarcomas. | | Dosage :- | 1.2-2.4 mg/kg body wt or 60-75 mg/sq metre of body surface given as a single dose every 3 week by slow i.v. inj. | | Contra Indications :- | Cardiac disease. Hepatic dysfunction. | | Special Precautions :- | ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure. | | Paediatrics : | Reduced dose necessary. | | Pregnancy :- | Not usually prescribed. | | Lactation :- | Not prescribed. | | Elderly :- | Reduced dose may be necessary. | | Side Effects :- | Cardiotoxicity, alopecia, Bone marrow depression, alopecia, cardiomyopathy, stomatitis, vomiting and local tissue damage. | | Drug Interactions :- | Cyclosporin, cardiotoxic agents potentiates the cardiotoxicity. | | Purity : | Not less than 99%. |
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