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Home - Products - Oncology(Anti-Cancer-Injectables) - Doxorubicin Injection

Doxorubicin Injection

Category: Anti neo-plastic
Each vial contains:-
Doxorubicin….. 10mg and 50mg
Quality Specification:
Chromatographic Purity: NLT 99%

It is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase.

Composition : Each vial contains:
DoxorubicinHydrochloride………….10mg, 50mg, 100mg
Lactose Monohydrate ………………..50mg, 200mg, 500mg
Indications : Doxorubicin has been used successfully to produce regression in disseminated neoplastic conditions such as acute lymphoblastic leukemia, acute myeloblasticleukemia, Wilms' tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin's disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types.
Contraindications : In patients with history of hypersensitivity to the drug, pregnancy, location.
Pharmacological action: : It is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase
Adverse Effects : : Cardiotoxicity, alopecia, Bone marrow depression, alopecia, cardiomyopathy, stomatitis, vomiting and local tissue damage.
Dosage : 1.2-2.4 mg/kg body wt or 60-75 mg/sq metre of body surface given as a single dose every 3 week by slow i.v. inj. Doxorubicin has been used concurrently with other approved chemotherapeutic agents. Evidence is available that in some types of neoplastic disease combination chemotherapy is superior to single agents. The benefits and risks of such therapy continue to be elucidated. When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 given as a single intravenous injection every 21 to 28 days.
Drug interaction: Doxorubicin is extensively metabolized by the liver. Changes in hepatic function induced by concomitant therapies may affect doxorubicin metabolism, pharmacokinetics, therapeutic efficacy, and/or toxicity. Toxicities associated with doxorubicin, especially hematologic and gastrointestinal events, may be increased when doxorubicin is used in combination with other cytotoxic drugs.
Precautions: ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure.Doxorubicin may cause heart problems, including possibly fatal heart failure. Heart problems may occur durin doxorubicin therapy or months to years after receiving this medication
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