| Category: Anticancer MANUFACTURER
Each vial contains:-
Doxorubicin….. 10mg and 50mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
It is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase.
| Composition : | 10mg/5ml, 50mg/25ml | | Indication : | Malignant lymphoma. Gastro-intestinal tract carcinoma. Bronchogenic, bladder, breast & overian carcinoma. Wilm’s tumour. Acute my eloblastic leukaemia. Soft tissue & bone sarcomas. | | Dosage :- | 1.2-2.4 mg/kg body wt or 60-75 mg/sq metre of body surface given as a single dose every 3 week by slow i.v. inj. | | Contra Indications :- | Cardiac disease. Hepatic dysfunction. | | Special Precautions :- | ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure. | | Paediatrics : | Reduced dose necessary. | | Pregnancy :- | Not usually prescribed. | | Lactation :- | Not prescribed. | | Elderly :- | Reduced dose may be necessary. | | Side Effects :- | Cardiotoxicity, alopecia, Bone marrow depression, alopecia, cardiomyopathy, stomatitis, vomiting and local tissue damage. | | Drug Interactions :- | Cyclosporin, cardiotoxic agents potentiates the cardiotoxicity. | | Purity : | Not less than 99%. |
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