Category: Anti-neoplastic
Each ml contains:- Granisetron Hydrochloride eq.to Granisetron . 1mg, water for injection -qs
Pack Size:- 1ml and 3ml vial
Granisetron is a white to off-white solid that is readily soluble in water and normal saline at 20°C. Granisetron Injection is a clear, colorless, sterile nonpyrogenic, aqueous solution for intravenous administration. pH ranges from 4.7 to 8.0. Empirical formula is C18H24N4O•HCl,
| Composition : | Each ml contains:-
Granisetron Hydrochloride
eq.to Granisetron …………….1mg,
water for injection --------------qs | | Indication : | Granisetron Injection is a serotonin-3 (5-HT3) receptor antagonist indicated for the prevention of nausea and/or vomiting associated with initial and repeat courses of emetogenic cancer therapy, including high-dose cisplatin. | | Dosage :- | Adult-10mcg/kg intravenously within 30 minutes before initiation of chemotherapy.
Children-2-16 yrs of age : 10mcg/kg | | Contra Indications:- | Granisetron Injection is contraindicated in patients with known hypersensitivity (eg. anaphylaxis, shortness of breath, hypotension, urticaria) to the drug or to any of its components. | | Precautions:- | Granisetron Injection should not take if any of following condition are present-
Nasogastric Suction ,Hypersensitivity Reaction , Carcinogensis, mutagensis | | Pharmacological Action: | Serotonin receptors of the 5-HT3 type are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. During chemotherapy-induced vomiting, mucosal enterochromaffm cells release serotonin, which stimulates 5-HT3 receptors. This evokes vagal afferent discharge and may induce vomiting. | | Drug interaction: | Granisetron does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system in vitro. There have been no definitive drug-drug interaction studies to examine pharmacokinetic or pharmacodynamic interaction with other drugs; however, in humans. | | Side effects: | Headache, diarrhea, dizziness, fever, or pain/redness/swelling at the injection site may occur. If any of these effects persist or worsen, tell your doctor promptly. | | | | Storage: | Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. |
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