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Home - Products - Oncology(Anti-Cancer-Injectables) - Ifosfamide Injection

Ifosfamide Injection

Category: Anti-neoplastic
Composition- : Each lyophilized vial contains :- Ifosfamide USP…………...1gm/2 gm
Ifosfamide is an alkylating agent.Following activation in the liver, ifosfamide interfare with Dna through formation of phosphotriesters and DNA-DNA crosslinks, thereby inhibiting protein synthesis and DNA synthesis.

Specification- pH range – : 4.0 to 7.0
Description-: Ifosfamide belongs to the group of medicines called alkylating agents. It is used to treat cancer of the testicles as well as some other kinds of cancer. Another medicine, called mesna, is usually given along with ifosfamide to prevent bladder problems that can be caused by ifosfamide.
Indication : Ifosfamide , used in combination with certain other approved antineoplastic agents, is indicated for third line chemotherapy of germ cell testicular cancer. It should be used in combination with a prophylactic agent for hemorrhagic cystitis.
Dosage :- Ifosfamide should be administered intravenously at a dose of 1.2 g/m² per day for 5 consecutive days. Treatment is repeated every 3 weeks or after recovery from hematologic toxicity.
Contra Indications:- Continued use of ifosfamide is contraindicated in patients with severely depressed bone marrow function ifosfamide is also contraindicated in patients who have demonstrated a previous hypersensitivity to it.
Precautions:- Ifosfamide should be discontinued if neurologic symptoms of somnolence, irritability, anxiety, confusion, hallucinations, or coma are observed. Use with caution in patients with renal or hepatic impairment.
Drug interaction: The concurrent use of ifosfamide may enhance the anticoagulant effect of warfarin and thus raise the risk of haemohorrage .
Side Effect-: Severe nausea, vomiting, Dizziness, Fatigue, Bone marrow depression and Allergic reaction like difficult breathing and swelling of face and lips.
Storage: Store at 2-8ºC (35-46ºF) and protect from light.
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