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Home - Products - Oncology(Anti-Cancer-Injectables) - L-Asparaginase Injection

L-Asparaginase Injection

Category: Antineoplastic
Composition- : Each vial contains: L-Asparaginase 5000IU/10000 IU
The rationale behind asparaginase is that it takes advantage of the fact that ALL leukemic cells are unable to synthesize the non-essential amino acid asparagine, whereas normal cells are able to make their own asparagine; thus leukemic cells require high amount of asparagine. These leukemic cells depend on circulating asparagine. Asparaginase, however, catalyzes the conversion of L-asparagine to aspartic acid and ammonia. This deprives the leukemic cell of circulating asparagine.

Specification- Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. It is used for the treatment of acute lymphoblastic leukemia (ALL)[1] and is also used in some mast cell tumor protocols. [2] Unlike other chemotherapy agents, it can be given as an intramuscular, subcutaneous, or intravenous injection without fear of tissue irritation.
Indication : Acute leukaemia, Malignant lymphoma.
Dosage :- 50-200 k.u/kg body wt. daily or every alternate day by I.V infusion.
Contraindications:- • Hypersensitivity or previous serious allergic reaction (such as generalized urticaria, bronchospasm, laryngeal edema, hypotension) to drug.
• Pancreatitis or history of pancreatitis.
• Previous hemorrhagic events related to L-asparaginase therapy
Precautions:- • renal or hepatic disease, CNS disorders.
• concurrent use of hepatotoxic agents, anticoagulants, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs)
• pregnant or breastfeeding patients.
Drug interaction: Vincristine and prednisolone increases the toxicity, diminishes or abolishes the effect of methotrexate on malignant cells.
Adverse Effect-: The main side effect is an allergic or hypersensitivity reaction; anaphylaxis is a possibility.[1] Asparaginase has also been associated with pancreatitis. Additionally, it can also be associated with a coagulopathy as it decreases protein synthesis, including synthesis of coagulation factors (eg progressive isolated decrease of fibrinogen) and anticoagulant factor (generally antithrombin III; sometimes protein C & S as well), leading to bleeding or thrombotic events such as stroke.
Storage: Store between +2°C and +8°C.
Purity:- 100 %
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