| Observing the qualitative difference observed between normal cells and those from childhood lymphoblastic leukemia- the leukemia cells are deficient in L-asparagine synthetase and depend on the supply of L-asparagine from the medium. The enzyme L-asparaginase (from E. coil)degrades L-asparagine to L-aspartic acid,depriving leukemic cells of an essential metabolite - may cause cell death.
| Composition : | 5000 IU, 10000 IU | | Indications : | Acute leukemia. Malignant lymphoma. | | Dosage : | 50-200 k.u/kg body wt. daily or every alternate day i.v infusion
Contra - Indications: Hypersensitivity
Special Precautions: Anaphylaxis can occur, al-lergic reaction (being a foreign protein).
Paediatrics : Safe
Pregnancy : Should not be used.
Lactation : Should not be used
Lactation : Should not be used
Side - effects : Liver damage, pancreatitis & C.N.S symptoms (due to effective protein synthesis)
Drug Interactions: Vincristine and prednisolone increases the toxicity, diminishes or v abolishes the effect of methotrexate on malignant cells.
Leunase ( L -asparaginase) Biochem
Inj 5,000 K.U vial 1040.00 873.60
10,000K.U vial 1497.00 1254.96 | | Purity : | Not less than 99%. | |
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