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Leucovorin Injection

Leucovorin is one of several active,chemically related derivatives of folic acid. It is also known as folinic acid, citrovorum factor. It is useful as an antidote to drugs which act as folic acid antagonists as it does not need activation by DHFR are before it can act.
Composition : 3mg/ml, 15mg/2ml, 50mg/5ml
Indications : Leucovorin is administered to diminish the toxicity and counteract the effect of impaired methotrexate elimination and inadvertent overdosage of folic acid antagonists. Leucovorin is also indicated in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
Contraindications : Leucovorin is improper therapy for pernicious anaemia and other megaloblastic anemias secondary to lack of vitamin B12 A. haematologic remission may occur while neurologic manifestations continue to progress.
Safety Profile : Pregnancy : Should be given only if clearly indicated.
Lactation : Caution should be exercised.
Paediatric use : Might interact with antiepileptics in children.
Adverse Effects : Allergic sensitisation including urticaria and anaphylactoid reactions. Nausea, pyrexia and vomiting have been observed.
Drug Interactions:Might decrease the efficacy of antiepileptic medications like phenobarbitone, phenytoin and primodone. Enhances cytotoxic effect of fluorouracil reduces methotrexate toxicity.
Dosage :Dose equal to the antagonist is given within one hour and is ineffective if given after 3 hours.
Purity :Not less than 99%.
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