Category: Chemoprotectant/Cytoprotective Agent/ Antidotes
Composition- : Each ml contains: Mesna 100mg Water for Injection q.s.
Mesna is used to reduce the incidence of ifosfamide-induced hemorrhagic cystitis. Mesna disulfide is reduced to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites, resulting in their detoxification.
| Specification- | pH range – : 4.5 to 7.0
Mesna Injection is a detoxing agent to inhibit the hemorrhagic cystitis induced by ifosfamide. It is a sterile, nonpyrogenic, aqueous solution of clear and colorless to light pink appearance in clear glass multidose vials for intravenous administration. It is used to prevent bleeding from the bladder during ifosfamide or cyclophosphamide chemotherapy. | | Indication : | Prevention of toxicity to the urinary passage caused by cyclophosphamide or Trofosfamide. | | Dosage :- | I.V. 20% of the dose of anti-neoplastic on weight basis, over 15-30 minutes at 4 hours interval | | Contraindications:- | Hypersensitivity. | | Precautions:- | Tell your doctor and pharmacist if you are allergic to mesna or any other drugs.
Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.
Tell your doctor if you have or have ever had liver or kidney disease.
Tell your doctor if you are pregnant or breast-feeding. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy.
Do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor. | | Drug interaction: | Mercaptopurine, Cyclophosphamide, Barbiturates, Digoxin. | | Adverse Effect-: | G.I. Disturbance, headache, skin rash, tachycardia, hypotension | | Storage: | After preparation, this medication is stable for 24 hours at 77 degrees F (25 degrees C). Before preparation, store the vials at room temperature between 59 and 86 degrees F (15-30 degrees ) | | Purity:- | 99.5% |
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