| Omeprazole is a gastric proton pump inhibitors. This prodrug is a substituted benzimidazole derivative which acts on the final step of gastiric acid production and therefore controls acid secretion in response to all varieties of stimuli, omerprazole has prolonged action in a dose of 20-40mg once a day and reduces the 24 hours gastric acid output by almost 90%. It is highly effective in Zollinger-Ellison syndrome, recurrent duodenal ulcers & reflux oesophagitis. It also suppresses H-pylori. It should be taken before meals. |
|Composition : ||20mg |
|Indications : ||Duodenal & gastric ulcers, NSAIDs induced ulcers, Zollinger-Ellison syndrome, reflux oesophagitis. |
|Contraindications : ||Hypersensitivity, pregnancy, lactation, children. |
|Safety Profile : ||Exclude the gastric malignancy, renal & hepatic dysfunction, epilepsy, avoid its use with alcohol. |
|Adverse Effects : ||Skin rashes, abdominal colic, diarrhoea, nausea, dry mouth, dizziness, headache, constipation & flatulence, increased risk of enteric infections due to reduced acid secretion. |
|Drug Interactions : ||Diazepam, phenytoin, warfarin, cyclosporine & digoxin.|
|Dosage:||Peptic ulcers - 20mg once daily for 4 weeks max up to 8 weeks.|
Reflux oesophagitis-20-40mg once daily for 4-8 weeks.
Z.E.S. - 60mg once daily to start than 20-120mg daily in 2 divided dose.
|Purity :||Not less than 99%.|| |