Intravenous general anaesthetic produces rapid induction and rapid recovery with small hangover effect. It is generally used for induction and maintenance of anaesthesia. Propofol has specific Antiemetic action without any effect on hypnotic, pulmonary and vascular reflexes.
Mechanism of action : Propofol inhibits the excitatory and excites, the inhibitory synopses by binding
Ligand gated on channels especially the post. Synaptic GABA receptor. May also cause calcium channel medicated cardiac depression.
| Composition : | 100mg/ 10ml, 200mg/20ml, 500mg/50mlz | | Pharmacokinetics : | IV administration result in rapid distribution into the brain and other sites with metabolic clearance followed by slow distribution and significant metabolism plasma protein binding is high (>95%) Crosses placental barrier & milk barrier. Excreted mainly in urine
Onset of action 1-3 minutes
Duration of action 10-15 minutes | | Indications : | Induction & maintenance of anaesthesia, short surgical procedures, status epilepticus. | | Contraindications : | Hypersensitivity, any condition where CNS depressants or general anaesthesia itself is contraindicated, pregnancy & lactation | | Safety Profile : | Hypovolaemia, epilepsy, dyslipidaemia, increased intracranial pressure. It is not recommended in children below 12 years. | | Purity : | Not less than 99%. | |
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