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Home - Hormones - Somatostatin

Somatostatin

It is synthetic cyclic tetradecapeptide with structure of hypothalamic hormone that inhibits release of growth hormone.

Composition : 250mcg
Indications : Acute bleeding oesophageal varices, upper GI bleeding from haemorrhagic gastritis or gastric/duodenal ulcer, intestinal and pancreatic fistulae. Hypersecretory tumours of intestinal tract.
Contraindications : Hypersensitivity.
Safety Profile :Monitor blood glucose levels.
Adverse Effects :Flushing, nausea, bradycardia, dyspepsia, steatorrhoea, hypochlorhydria, diarrhoea.
Dosage :Bleeding oesophageal varices – i.v. bolus of 250mcg followed by 6mg/day. Continuous infusion for 5 days. Upper GI bleeding – 250mcg IV bolus followed by 3mg/12 hrly for 2-3 days. Intestinal and pancreatic fistulae – 6mg/day i.v. for 14 days.
Purity :Not less than 99%.
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Somatostatin
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