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Verapamil Injection

It has potent antiarrhythmic activity more so in supraventricular arrhythmias because of its potent calcium channel blocking property. Same activity is responsible for its antianginal and antiischemic action.
Composition : 5mg/ 2ml
Indications : PSVT, atrial flutter/fibrillation with tachyarrhythmias and pre mature beats. Angina pectoris, chronic coronary insufficiency, variant angina, hypertension.
Contraindications : Acute M.I., cardiovascular shock, severe AV block and sick sinus syndrome.
Safety Profile : Ability to do skilled job may be impaired, hepatic & renal impairment.
Adverse Effects : Constipation, nausea, vertigo, dizziness, headache, flushing, faigue, ankle oedema, erythromelalia and paraesthesia.
Drug Interactions : Antihypertensives including beta blockers, neuromuscular blockers, digitalis and carbamazepine actions repotentiated. Use with quinidine may cause cardiac depression.
Dosage : Adults - 40-80 mg 2-3 times daily orally. i.v. dose 5mg slowly, repeat further 5mg if needed, children - upto 6 yrs. 40-80mg twice a day, 6-12 yrs - 40-120mg twice a day.
Purity :Not less than 99%.
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