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Home - Products - Oncology(Anti-Cancer-Injectables) - Vinblastine Injection

Vinblastine Injection

It inhibits micro tubule formation in the mitotic spindle thus arresting cell division in meta phase.
Category: Antineoplastics.
Composition : Each vial contains
Vinblastin Sulphate USP…….. 1.0mg

Indications : Vinblastine sulfate (vinblastine sulfate injection) is indicated in the treatment of the following:
• Frequently Responsive Malignancies
• Generalized Hodgkin's disease
• Lymphocytic lymphoma (nodular and diffuse, poorly and well differentiated)
• Histiocytic lymphoma
• Mycosis fungoides (advanced stages)
• Advanced carcinoma of the testis
• Kaposi's sarcoma
• Letterer-Siwe disease
• Less Frequently Responsive Malignancies
• Choriocarcinoma resistant to other chemotherapeutic agents
• Carcinoma of the breast, unresponsive to appropriate endocrine surgery and hormonal therapy

.
Contraindications : Pregnancy. Granulocytopenia, Bacterial infections.

Adverse Effects : Hair loss, leucopenia, neuritic pain, constipation, sensory loss, paresthesias, difficulty in walking (stepping gait), loss of deep tendon reflexes, muscle wasting, fever, hypersensitivity reaction, weight loss, polyuria, urinary retention, hypertension, hypotension, cranial nerve palsy, headache, bone pains, jaw pain, parotid pain, myalgia, convulsions, syndrome of inappropriate secretion of ADH..
Dosage : Given I.V. at weekly intervals. Children : 2mg/m2 (if <10kg, start with 0.005 mg/kg/week) adult : 1.4mg/m2. Decrease the dose to 50%, if S. bilirubin is >3mg/dl. Not given to patients getting radiation therapy through ports that include liver.
Precautions: Toxicity may be enhanced in the presence of hepatic insufficiency.
• Acute uric acid nephropathy,
• Acute shortness of breath
severe broncospasm have been reported following the administration of vinca alkaloids.
Storage 2-8°c
.
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