| It inhibits microtubule formation in the mitotic spindle thus arresting cell division in metaphase.
| Composition : | 1mg/1ml,10mg/10ml | | Indications : | Acute leukemias,lymphomas,demyelinating from of charcot Marie tooth disease,advanced Ca of testis mycosis. | | Contraindications : | Used only by i.v. route. Considerable irritation can occur if extravasated into surrounding tissue local injection of hyaluronidase & moderate heat will minimize the discomfort. | | Adverse Effects : | Hair loss, leucopenia, neuritic pain, constipation, sensory loss, paresthesias, difficulty in walking (stepping gait), loss of deep tendon reflexes, muscle wasting, fever, hypersensitivity reaction, weight loss, polyuria, urinary retention, hypertension, hypotension, cranial nerve palsy, headache, bone pains, jaw pain, parotid pain, myalgia, convulsions, syndrome of inappropriate secretion of ADH. | | Drug Interactions : | If given with phenytoin, there is increased seizure activity. Acute bronchospasm with mitomycin-C | | Dosage : | Given I.V. at weekly intervals. Children : 2mg/m2 (if <10kg, start with 0.005 mg/kg/week) adult : 1.4mg/m2. Decrease the dose to 50%, if S. bilirubin is >3mg/dl. Not given to patients getting radiation therapy through ports that include liver. | | Purity : | Not less than 99%. |
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