It is a semi-synthetic vinca alkaloid. It interfere with microtubules, which compose of miotic spindle fibres leading to cell cycle arrest in the metaphase.
| Composition : | 10mg/1ml,20mg/5ml,50mg/5ml | | Indications : | Non small cell lung carcinoma, breast carcinoma, Hodgkin's disease, ovarian carcinoma, squamous cell carcinoma of the head and neck, cervical, SCLC, renal cell cancer and kaposi's sarcoma. | | Contraindications : | Hypersensitivity, intrathecal administration as it is extremely irritating. | | Safety Profile : | Monitor patients with pre-existing neuropathy. Careless causes extravasation. | | Adverse Effects : | Granulocytopenia, anaemia thrombocytopenia, vomiting, nausea, muscle weakness. | | Dosage : | Initial dose of 30mg/m² weekly over a period of 6-10 min. No dose adjustment is required for renal insufficiancy. | | Purity : | Not less than 99%. | |
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